The four men who did see improvements were the same men who had been most negatively affected by the high altitude to begin with. At high altitude, however, four of the men showed increased oxygen content of the arteries and great improvements in their time trials when taking sildenafil. The participants in the study performed both moderate exercise and a time trial (10k at sea level and 6k at high altitude) after either taking no pill, a placebo pill, or sildenafil.

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